The numbers in the segments of the top left circle equal the sum of the numbers in corresponding segments of the lower two circles, and the numbers in the top right circle equal the difference between numbers in corresponding segments of the lower two circles.
Starting at the top left and working down, then to the right and up, and finally to the right and down in a zig-zag shape, numbers follow the repeated sequence, subtracting 1 then adding 3 etc.